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Sevelamer hydrochloride

Sevelamer hydrochloride
Listing Began:
Wed, 10 Jan 2018 15:49:36 +0800
1095 Days
$10 USD

Product Name:Sevelamer hydrochloride
Product Categories:Pharmaceutical intermediate;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs;Inhibitors
Mol File: 152751-57-0.mol

Tumor lysis syndrome is a large number of tumor cells died rapidly, the intracellular components released into the cycle, leading to including hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia and other metabolic disorders, the final occurrence of acute oliguria Failure.
The most serious consequence of hyperkalemia is fatal arrhythmia.
Hyperphosphatemia is a common metabolic complication of tumor lysis syndrome that reduces renal function, leading to a further reduction in urinary potassium and phosphate excretion.
Hypocalcemia is the consequence of hyperphosphatemia, can cause muscle spasms, arrhythmia and so on.
Hyperphosphatemia can be treated with phosphate binding agent. In addition, as far as possible without the use of phosphorus-containing drugs, to avoid eating high-phosphorus food.
By regulating the level of phosphorus, hypocalcemia can be self-correcting. When patients with symptoms should be treated with calcium gluconate.
Siwei Lame is a commonly used phosphate binding agent that delays the absorption of phosphate from the intestine and binds to phosphate in the digestive tract food into insoluble calcium phosphate. Adult recommended starting from 800 ~ 1600mg tid. Adverse reactions are nausea and vomiting, constipation, diarrhea and so on.
Hydrochloride has no systemic absorption, so high safety, can effectively control the blood phosphorus value and will not lead to side effects such as hypercalcemia, October 30, 1998 approved by the US Food and Drug Administration Genzyme Generals and GelTex Two pharmaceutical companies produce Strawamine hydrochloride tablets (trade name Renagel) for the treatment of hyperphosphatemia in patients with advanced kidney disease who are hemodialysis, and also the role of siviram hydrochloride combined with calcitriol , Control of renal failure patients with parathyroid hormone levels.
Clinically, high levels of phosphorus may lead to fatal complications in patients with hemodialysis, whereas stilbene hydrochloride can combine and remove phosphorus in the digestive tract and normal digestion process without causing high levels of conventional treatment Calcium deficiency.
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